Safe Shipping sarms GW0742 powder with 99% purity cas:317318-84-6 Bene

Canberra | Added: 23 june 2022, number: 278806

Safe Shipping sarms GW0742 powder with 99% purity cas:317318-84-6 Bene, 20$, You can bargain

Canberra | 23 june 2022, Wuhan Demeikai Biotechnology Co.,td., номер: 278806, просмотры: 29

Адрес: Canberra,, Show on the map

  • Condition: New 
Sarms GW0742
Purity:99% HPLC
Packing:10g,100g,500g and 1kg
Min Order: Powder---10gram
Payment:Bitcoin,Moneygram and Wester Union
Lead time:24hours after received payment
Safe shipping to US and most of Europe country
Benefit:The effects of a high-affinity PPAR-β/δ agonist, GW0742, in a mouse model of carrageenan (CAR)-induced pleurisy. Injection of CAR into the pleural cavity of mice elicited an acute inflammatory response characterized by accumulation of fluid containing a large number of neutrophils (polymorphonuclear leukocytes) in the pleural cavity, infiltration of polymorphonuclear leukocytes in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate, TNF-α, and IL-1β. Furthermore, CAR induced lung apoptosis (Bax and Bcl-2 expression), and nitrotyrosine formation was determined by immunohistochemical analysis of lung tissues. Administration of GW0742 (0.3 mg/kg, i.p. bolus) 30 min before and 30 min after a challenge with CAR caused a reduction in all the parameters of inflammation measured. Thus, based on these findings, we propose that a PPAR-β/δ agonist such as GW0742 may be useful in the treatment of various inflammatory diseases.
Application:GW0742 is a potent and selective agonist for PPARδ, a member of the PPAR subfamily of the nuclear receptor superfamily of transcription factors. It has been shown to reduce atherosclerosis in LDLR-/- mice, to exert protective actions in an autoimmune model of demyelinating disease, and to induce differentiation and inhibit proliferation in keratinocytes.
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